We are located in the Joseph Gottstein Laboratories in the Department of Pathology.  Our research is centered on the molecular biology of mutagenesis, and our goal is to understand the relationships between DNA damage, mutations and cancer. Our current work involves the study of the fidelity of DNA replication, an analysis of mutator phenotypes in human cancers, the creation of new enzymes for cancer gene therapy, the relationship of mutations to aging, and the prevention of HIV replication by mutagenic nucleoside analogs.

The diversity of our interests results in part from the prior funding of our laboratory by an Outstanding Investigator Grant from the National Cancer Institute that was designed to support high-risk research projects. Current support is provided by NIH RO1 grants from NCI and participation in Program Project Grants from the NCI and NIA.  Our annual retreats have been funded by the Alhadeff family.